Asked by: Lucelly Wrasmann
asked in category: General Last Updated: 9th May, 2020

What is corneal graft rejection?

Definition of rejection vs failure:
The term graft rejection refers to a specific immunologic response of the host to the donor corneal tissue. The incidence of rejection is greatest in the first year-and-a-half following transplant but can occur up to 20 years or more after surgery.

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Simply so, what are the symptoms of corneal transplant rejection?

No symptoms are related universally to corneal graft rejection, although astute patients may complain of the following:

  • Decrease in visual acuity.
  • Redness.
  • Pain.
  • Irritation.
  • Photophobia.

Similarly, what happens when a corneal transplant fails? Failure can occur for a number of reasons, the most common one being endothelial decompensation, either due to graft rejection or "endothelial exhaustion," where enough of the endothelial cells die off and the cornea becomes edematous. When this occurs, the cornea becomes cloudy and vision worsens.

why is a cornea transplant rejected?

Rejection is unusual after corneal transplantation because the cornea usually does not have blood vessels. Without blood vessels the body's immune system is less likely to recognise and reject the “foreign” graft. The cornea in patients with endothelial disease does not usually have blood vessels.

How long does a corneal graft last?

It's important to understand that the transplant will not last forever. How long it lasts depends on the reason for the transplant. For example, a transplant in a patient with keratoconus usually lasts 15 to 20 years.

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